Avoid use of live attenuated vaccines. May increase serum K w/ K-sparing & K-containing drugs. Increased AUC w/ lercanidipine. Risk of synergy w/ MTX. Increased/decreased plasma or whole blood levels w/ CYP3A4. Increased levels w/ macrolides (eg, erythromycin, azithromycin, clarithromycin), ketoconazole, fluconazole, itraconazole, voriconazole, diltiazem, nicardipine, verapamil, metoclopramide, OCs, danazol, methylprednisolone (high dose), allopurinol, amiodarone, cholic acid & derivatives, PIs, imatinib, colchicine, nefazodone. Potential increased nephrotoxicity w/ aminoglycosides (gentamycin, tobramycin), amphotericin B, ciprofloxacin, vancomycin, trimethoprim (sulfamethoxazole), NSAIDs (including diclofenac, naproxen, sulindac), melphalan, H
2-receptor antagonists (eg, cimetidine, ranitidine), tacrolimus, MTX. Reversible kidney impairment w/ fibric acid derivatives (eg, bezafibrate, fenofibrate). Increased risk of gingival hyperplasia w/ nifedipine. May increase levels of CYP3A4 & multidrug efflux transporter P-gp. May reduce clearance of digoxin, colchicine, prednisolone, HMG-CoA reductase inhibitors (statins), etoposide, aliskiren, bosentan or dabigatran. Severe digitalis toxicity w/ digoxin. Myotoxicity, myositis & rhabdomyolysis w/ lovastatin, simvastatin, atorvastatin, pravastatin & (rare) fluvastatin. Increased blood levels of everolimus & sirolimus. May increase plasma conc of repaglinide. Increased exposure w/ ambrisentan & anthracyclines (eg, doxorubicin, mitoxanthrone, daunorubicine).